Discovery of alkenylboronic acids as neuroprotective agents affecting multiple biological targets involved in Alzheimer's disease
K Jiménez-Aligaga, P Bermejo-Bescós… - Bioorganic & medicinal …, 2013 - Elsevier
Alkenylboronic acids have shown important biological activities that contribute to
neuroprotection. We have determined their influence on the β-amyloid (βA) aggregation
process, β-secretase and acethylcholinesterase activities on cell-free systems, on the redox
and lipid peroxidation status, and on the vulnerability to apoptotic death in an APPswe
neuroblastoma cell line, before and after hydrogen peroxide treatment. We have discovered
that 2-arylvinylboronic acids and some of their esters possess a set of properties which …
neuroprotection. We have determined their influence on the β-amyloid (βA) aggregation
process, β-secretase and acethylcholinesterase activities on cell-free systems, on the redox
and lipid peroxidation status, and on the vulnerability to apoptotic death in an APPswe
neuroblastoma cell line, before and after hydrogen peroxide treatment. We have discovered
that 2-arylvinylboronic acids and some of their esters possess a set of properties which …
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